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Vitamin E deficiency is rare in humans. There are three specific situations when a vitamin E deficiency is likely to occur.

1. persons who cannot absorb dietary fat due to an inability to secrete bile or with rare disorders of fat metabolism are at risk of vitamin E deficiency.

2. individuals with rare genetic abnormalities in the alpha-tocopherol transfer protein are at risk of vitamin E deficiency; and

3. premature, very low birth weight infants (birth weights less than 1500 grams, or 3 pounds, 4 ounces) are at risk of vitamin E deficiency.

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